Whole Animal Automated Platform for Drug Discovery against Multi-Drug Resistant Staphylococcus aureus
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منابع مشابه
Whole Animal Automated Platform for Drug Discovery against Multi-Drug Resistant Staphylococcus aureus
Staphylococcus aureus, the leading cause of hospital-acquired infections in the United States, is also pathogenic to the model nematode Caenorhabditis elegans. The C. elegans-S. aureus infection model was previously carried out on solid agar plates where the bacteriovorous C. elegans feeds on a lawn of S. aureus. However, agar-based assays are not amenable to large scale screens for antibacteri...
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Multi-drug resistant Staphylococcus aureus (MDRSA) remains a great challenge despite a decade of research on antimicrobial compounds against their infections. In the present study, various acyclic amines and diamines were chemically synthesized and tested for their antimicrobial as well as antibiofilm activity against MDRSA. Among all the synthesized compounds, an acyclic diamine, (2,2'-((butan...
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BACKGROUND Community-acquired haematogenous Staphylococcus aureus pneumonia is a rare infection, though it can be acquired nosocomially. Currently, antibiotics used against S. aureus pneumonia have shown reduced efficacy. Thus, there is need for an alternative therapy against multidrug-resistant S. aureus (MDRSA) strains in the community. OBJECTIVE We sought to determine the efficacy of envir...
متن کاملDrug-resistant Streptococcus pneumoniae and Methicillin-resistant Staphylococcus aureus Surveillance1
Conference Summary Drug-resistant Streptococcus pneumoniae and Methicillin-resistant Staphylococcus aureus Surveillance 1 The Centers for Disease Control and Prevention (CDC) convened a conference on March 12–13, 2003, in Atlanta, Georgia, to discuss improving state-based surveillance of drug-resistant Streptococcus pneumoniae (DRSP) and methicillin-resistant Staphylococcus aureus (MRSA). The C...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0089189